Mast Cell Stabilizer (Ketotifen) in Fibromyalgia
نویسندگان
چکیده
منابع مشابه
Ophthalmic Mast Cell Stabilizer/Antihistamines For Seasonal Allergic Conjunctivitis
MCS/AHs do not cause rebound congestion with prolonged use (> 3 days), unlike first-line antihistamine/decongestion products. Ophthalmic MCS/AHs block histamine-1 receptors and inhibit the release of histamine from mast cells. Histamine receptor blockage occurs instantly, but preventing mast cell degranulation may take up to 2-4 weeks. This dual approach decreases the signs and symptoms of AC, ...
متن کاملMast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat.
Trichinella spiralis infection in rats induces hypermotility and an abnormal response to cholecystokinin (CCK) similar to motor disturbances observed in irritable bowel syndrome. Mast cell hyperplasia is also characteristic of this experimental model. The aim of our study was to correlate mast cell activity with the development of dysmotility and to demonstrate whether the mast cell stabilizer ...
متن کاملP-4: Zaditen (Ketotifen), as Mast Cell Blocker, Improves Sperm Quality, Chromatin Integrity and Pregnancy Rate after Varicocelectomy
Background: Surgery is considered the most common choice for the treatment of male infertility with clinical varicocele. Increased numbers of mast cells (MCs) have been associated with different types of infertility, including varicocele. Despite there being different reports on improved fertility following administration of MC blockers, there is no report on the effect of a MC blocker on varic...
متن کاملAnti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties.
BACKGROUND Anti-allergic drugs, such as tranilast and ketotifen, inhibit the release of chemokines from mast cells. However, we know little about their direct effects on the exocytotic process of mast cells. Since exocytosis in mast cells can be monitored electrophysiologically by changes in the whole-cell membrane capacitance (Cm), the absence of such changes by these drugs indicates their mas...
متن کاملInvolvement of mast cell chymase in burn wound healing in hamsters
Mast cells play a significant role in the late stage of wound healing following burn injuries. In the present study, the possible role of mast cell chymase in burn wound healing was examined using a mast cell membrane stabilizer, ketotifen, in hamsters. A total of 28 hamsters were randomly divided into two groups (n=14), termed as the control and ketotifen groups. A deep partial-thickness burn ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Clinical Journal of Pain
سال: 2015
ISSN: 0749-8047
DOI: 10.1097/ajp.0000000000000169